allergy to polyethylene glycol, propylene glycol, ethylene & butylene glycols

Links to Documentation of Glycol Allergies

Show These to Your Doctor

If your doc doesn’t believe it’s possible to have an allergy to polyethylene glycol, offer this link to a Danish study published in the journal Clinical and Experimental Allergy by Dr. Emily Cathrine Wenande. Dr. Wenande writes:

“This is an initial step in getting this rare but difficult condition recognised in the medical community at large. The review compiles all published cases of PEG hypersensitivity since 1977 (with many still surfacing at present), describing culprit agents, synonyms, symptoms, allergological testing (with an algorithm), potential immunological mechanisms and risk of cross-reactivity. Feel free to look it over and/or share it with your doctor.”

We are very grateful for Dr. Wenande’s research and look forward to hearing more from this powerful ally!

The below link goes to a place where you can rent the article for $6, purchase for cloud storage $12, or purchase for download for $38. It’s quick and easy to sign up. Click on this link, then go to the logo in the upper right corner for Wiley Online Library. (Fees for this article go to Wiley Online Library)
http://www.ncbi.nlm.nih.gov/pubmed/27196817

 Glycol Allergies – Additional Articles:

Here are links additional articles that may help with convincing your doctor that allergies to glycols exist.  If you find other sources – scientific papers or reports by medical experts, please let me know. Although COVID-19 has been a devastating calamity and I wish it were not so, the pandemic has brought attention to glycol allergies, and for that I am grateful.

Amber

PEG Allergy/PEG Sensitivity

Dr. Wenande’s Article: Immediate-type hypersensitivity to polyethylene glycols: a review

Allergy, Asthma & Clinical Immunology: Polyethylene glycol as a cause of anaphylaxis

Allergy, Asthma and Clinical Immunology: Anaphylaxis following a transvaginal ultrasound

Allergy: European Journal of Allergy and Clinical Immunology:  Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets 

American Academy of  Allergy Asthma & Immunology: Allergic Reaction Following Colonoscopy

American Academy of Allergy, Asthma & Immunology: Polyethylene Glycol

American Academy of  Allergy Asthma & Immunology Ask the Expert: Polyethylene Glycol Allergy

American Academy of Allergy, Asthma & Immunology Ask the Expert: Anaphylaxis following ingestion of docusate

Angewandte Chemie, A Journal of the German Chemical Society: Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Clinical and Experimental Allergy, 2016: Immediate‐type hypersensitivity to polyethylene glycols: a review

Clinical and Translational Allergy: Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

Contemporary Pediatrics: Harmful excipients for pediatric patients

Journal of Allergy & Clinical Immunology: Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized

Journal of Allergy & Clinical Immunology: Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis

Journal of Allergy & Clinical Immunology: Polyethylene Glycol: Not Just a Harmless Excipient

Journal of Allergy & Clinical Immunology: Macrogol hypersensitivity reactions during cleansing preparation for colon endoscopy

Journal of Allergy & Clinical Immunology: Polyethylene Glycol: Not just a harmless excipient

Journal of Clinical Pharmacology: A Case Series of Allergy to Polyethylene Glycol

National Library of Medicine: Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients 

National Library of Medicine: Hypersensitivity to polyethylene glycol in adults and children: An emerging challenge

National Library of Medicine: Hypersensitivity to polyethylene glycol (PEG)

National Library of Medicine: Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report

National Library of Medicine: Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions

National Library of Medicine: Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized

US National Library of Medicine, National Institutes of Health, 2017: Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

PG Allergy/PG Sensitivity

American Academy of Allergy, Asthma & Immunology Ask the Expert: Allergic contact dermatitis

American Academy of Allergy, Asthma & Immunology Ask the Expert: Cross-reactivity between propylene glycol and macrogol?

American Academy of Allergy, Asthma & Immunology Ask the Expert: Suspected anaphylaxis to cosmetic filler

American Academy of Allergy, Asthma & Immunology Ask the Expert: E-cigs: What Are They and How Are They Impacting Our Youth?

Skin Therapy Letter: Propylene Glycol: An Often Unrecognized Cause of Allergic Contact Dermatitis in Patients Using Topical Corticosteroids